St. Louis Blues vs Vegas Golden Knights prediction: Oct 22, Road Depth Edge

Game Information

Matchup/League: St. Louis Blues vs Vegas Golden Knights (NHL)
Venue: Enterprise Center, St. Louis

Scoring Depth | Vegas Tests St. Louis Beyond the First Layer

St. Louis is 4-4-1 with 29 goals scored and 29 allowed, while Vegas is 8-3-0 with a 44-30 goal profile and a 3-1-0 road record. The Blues just beat Winnipeg 2-1 behind tighter defensive-zone coverage and 32 saves from Joel Hofer, but Vegas had won three straight before its 6-2 loss to Tampa Bay and has shown a much higher offensive ceiling. The Golden Knights can attack through Jack Eichel, Mitch Marner, Mark Stone, and Tomas Hertl, giving them multiple ways to stress St. Louis when the Blues cannot exit cleanly. With the starting goaltender matchup still unconfirmed, the edge rests on Vegas' deeper scoring sample and stronger road form rather than a projected goalie advantage.

Special-Teams Pressure | Blues Need Their Penalty Kill to Hold

Vegas enters with a 25 percent power play, and Hertl has already scored three power-play goals, so St. Louis cannot afford repeated penalties against that second-wave scoring depth. The Blues answered their own special-teams questions against Winnipeg by going 3-for-3 on the penalty kill and scoring the winning goal on the power play through Philip Broberg. St. Louis is 2-0-1 at home and has shown a more disciplined forecheck when protecting a lead, which is the clearest path to making the favorite uncomfortable. The Vegas Golden Knights are the money-line pick because their stronger overall form, road record, and offensive depth provide the more reliable path across 60 minutes and beyond.

Quick Verdict

Vegas is available at a verified 1.85 money-line price, while St. Louis is 2.05. The Golden Knights own the better record, a 14-goal season differential, and enough power-play skill to punish a Blues team that cannot rely on another low-event game. The biggest risk is St. Louis' unbeaten regulation home record and a penalty kill that was sharp in its latest win. The recommendation is Vegas Golden Knights money line at 1.85.

Predicted Score: St. Louis Blues 3–4 Vegas Golden Knights